Johan Gabrielsson

Johan Gabrielsson is a Professor of Integrative Pharmacology. His research focuses on building numerical tools for the analysis of biomarkers in connection with drugs. Main areas is the study of the pharmacologic time course in animals and humans during drug treatment.

Research

His research concerns numerical methods for analysis of pharmacokinetic and pharmacodynamic (biomarkers) data. Several projects are sponsored by the pharmaceutical industry and in collaboration with the Fraunhofer-Chalmers Centre in Gothenburg, and Professor LA Peletier at Leiden University. SLU-related projects involve studies of cortisol turnover of horse by dexamethasone treatment. Target-mediated kinetics, dose-response-time analysis of pharmacological data and pattern recognition are other activities that are of great potential importance in drug development for both animals and humans.

Background

  • 1976-1985       Pharmacist, , PhD in Pharmacokinetics at Uppsala University
  • 1985-1991       Associate Professor of Pharmacokinetics Uppsala University, postdoctoral UCSF
  • 1991-2012       Sr. Principal Sci. @ AstraZeneca +20 years experience Dx research
  • 2012-               Professor of Integrative Pharmacology, VH/SLU

 

Selected publications

J. Gabrielsson, L.A. Peletier. Pharmacokinetic Steady-States Highlight Interesting Target-Mediated Disposition Properties. The AAPS Journal, 2017 DOI: 10.1208/s12248-016-0031-y

T. Cardilin, J. Almquist, M. Jirstrand, A. Sostelly, C. Amendt, S. El Bawab, J. Gabrielsson. Tumor Static Concentration Curves in Combination Therapy. The AAPS Journal, 19(2):456-467, 2017 DOI: 10.1208/s12248-016-9991-1

J. Gabrielsson, D. Weiner. Pharmacokinetic & Pharmacodynamic Data Analysis: Concepts and Applications, 5th ed., Swedish Pharmaceutical Press, ISBN-10 91 9765 100 1, ISBN-13 978 91 9765 100 4, 2016.

J. Gabrielsson, S. Hjorth, Pattern recognition in pharmacodynamic data analysis. The AAPS Journal, 2015 DOI: 10.1208/s12248-015-9842-5.

J. Gabrielsson, B. Meibohm, D. Weiner, Pattern recognition in pharmacokinetic data analysis. The AAPS Journal, 2015 DOI: 10.1208/s12248-015-9817-6.

J. Riviere, J. Gabrielsson, M. Fink, J. Mochel. Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics. J. vet. Pharmacol. Therap. doi: 10.1111/jvp.12278. 2015

R. Andersson, M. Jirstrand, L.A. Peletier, M. J. Chappell, N. D. Evans, J. Gabrielsson. Dose-response-time modelling: Second-generation turnover model with integral feedback control. Eur. J. Pharm. Sci. 2015

 

Links

Johan Gabrielsson

Johan Gabrielsson

Professor


Phone
+46 (0)18-67 31 72


E-mail
johan.gabrielsson@slu.se

Postal Address
BVF, Avd för farmakologi och toxikologi
Box 7028
SE-750 07 UPPSALA
Sweden