Johan Gabrielsson

Johan Gabrielsson is a Professor of Integrative Pharmacology. His research focuses on building numerical tools for the analysis of biomarkers in connection with drugs. Main areas is the study of the pharmacologic time course in animals and humans during drug treatment.

Research

His research concerns numerical methods for analysis of pharmacokinetic and pharmacodynamic (biomarkers) data. Several projects are sponsored by the pharmaceutical industry and in collaboration with the Fraunhofer-Chalmers Centre in Gothenburg, and Professor LA Peletier at Leiden University. SLU-related projects involve studies of cortisol turnover of horse by dexamethasone treatment. Target-mediated kinetics, dose-response-time analysis of pharmacological data and pattern recognition are other activities that are of great potential importance in drug development for both animals and humans.

Background

1976-1985 Pharmacist, , PhD in Pharmacokinetics at Uppsala University
1985-1991 Associate Professor of Pharmacokinetics Uppsala University, postdoctoral UCSF
1991-2012 Sr. Principal Sci. @ AstraZeneca +20 years experience Dx research
2012- Professor of Integrative Pharmacology, VH/SLU

Selected publications

J. Gabrielsson, L.A. Peletier. Pharmacokinetic Steady-States Highlight Interesting Target-Mediated Disposition Properties. The AAPS Journal, 2017 DOI: 10.1208/s12248-016-0031-y

T. Cardilin, J. Almquist, M. Jirstrand, A. Sostelly, C. Amendt, S. El Bawab, J. Gabrielsson. Tumor Static Concentration Curves in Combination Therapy. The AAPS Journal, 19(2):456-467, 2017 DOI: 10.1208/s12248-016-9991-1

J. Gabrielsson, D. Weiner. Pharmacokinetic & Pharmacodynamic Data Analysis: Concepts and Applications, 5th ed., Swedish Pharmaceutical Press, ISBN-10 91 9765 100 1, ISBN-13 978 91 9765 100 4, 2016.

J. Gabrielsson, S. Hjorth, Pattern recognition in pharmacodynamic data analysis. The AAPS Journal, 2015 DOI: 10.1208/s12248-015-9842-5.

J. Gabrielsson, B. Meibohm, D. Weiner, Pattern recognition in pharmacokinetic data analysis. The AAPS Journal, 2015 DOI: 10.1208/s12248-015-9817-6.

J. Riviere, J. Gabrielsson, M. Fink, J. Mochel. Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics. J. vet. Pharmacol. Therap. doi: 10.1111/jvp.12278. 2015

R. Andersson, M. Jirstrand, L.A. Peletier, M. J. Chappell, N. D. Evans, J. Gabrielsson. Dose-response-time modelling: Second-generation turnover model with integral feedback control. Eur. J. Pharm. Sci. 2015