Drugs of Natural Origin

A Treatise of Pharmacognosy


Edition: 
7th, revised
Publishing year: 2015
Author:
 Gunnar Samuelsson, Lars Bohlin
ISBN: 978-91-984078-1-5
Pages: 812
File size: 32 MB
Format: PDF

 47.92

Description

By Gunnar Samuelsson (professor emeritus) and Lars Bohlin (professor emeritus), Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Sweden.

During evolution, molecules have been developed for specific functions in nature. These bioactive substances have a potential as new drug candidates in drug development, but also as pharmacological tools, intermediates or templates for synthesis of drugs. This book deals with terrestrial and marine bioactive substances of plant, microbial or animal origin. The occurrence, biosynthesis, isolation, chemistry and medical use are described together with basic research strategies.

An increased understanding of the medical importance of bioactive natural products has developed in society. Since the publication of the sixth edition, six years ago, considerable progress has been achieved in the study of biosynthetic pathways, mainly based on gene technology. The revolution in high-throughput sequencing technology has given an increasing access to microbial genome sequences, which opens up new possibilities in the discovery of novel bioactive natural products. This development is reflected in a substantial revision and expansion of the book, but also removal of some sections containing products remotely associated with drugs. The new book also contains description of novel drugs marketed since the publication of the previous edition, especially in the field of diabetes, cancer and infection.

Drugs of Natural Origin is a unique multidisciplinary book suitable for undergraduate and graduate students and teachers in the area of natural product science, but also as a complementary book for disciplines like medicinal chemistry, biochemistry and pharmacology. The book can also serve society as a scientific source for the understanding of a sustainable use of natural products in the development of new drugs, scientifically based herbal remedies, and environmentally friendly biomolecules.

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Gunnar Samuelsson

Gunnar Samuelsson retired from the chair of Pharmacognosy at Uppsala University in 1991. His research activities comprised studies of plants containing biologically active proteins and plants used in traditional medicine in East Africa. Gunnar Samuelsson has been the sole author of editions 1–5 of this book.
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Lars Bohlin

Lars Bohlin has been professor of Pharmacognosy at the Faculty of Pharmacy, Uppsala University, Sweden from 1991 to 2015. He did his postdoctoral training with Professor Carl Djerassi at Stanford University and Professor Paul J. Scheuer at the University of Hawaii 1978–1981. His research covers a broad field of natural product research including structure-activity studies of natural products from both the rainforest and the marine environment. Lars Bohlin is engaged in many national and international commissions.
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